GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs867186 | 1 | rs55696836 | chr20:33549887 | PROCR | chr20:33758727-33765164:+ | -0.36 | -5.62 | 3.24E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs55696836 | chr20:33549887 | TRPC4AP | chr20:33590215-33680618:- | 0.32 | 3.82 | 0.00015 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs6878284 | 1 | rs55703459 | chr5:101691754 | SLCO4C1 | chr5:101569694-101632253:- | 0.25 | 5.62 | 3.21E-8 | Schizophrenia |
| THCA | cis | rs12107539 | 1 | rs55705054 | chr3:151007278 | GPR87 | chr3:151011876-151034636:- | 0.2 | 4.56 | 6.41E-6 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs55705054 | chr3:151007278 | P2RY14 | chr3:150929905-150996230:- | -0.2 | -4.22 | 2.95E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs4785204 | 1 | rs55707752 | chr16:50133570 | HEATR3 | chr16:50099881-50139373:+ | -0.41 | -5.8 | 1.18E-8 | Esophageal cancer (squamous cell) |
| THCA | cis | rs17772222 | 1 | rs55722539 | chr14:88878035 | SPATA7 | chr14:88852012-88904802:+ | -0.19 | -4.03 | 6.6E-5 | Coronary artery calcification |
| THCA | cis | rs7200543 | 1 | rs55727637 | chr16:15145252 | NTAN1 | chr16:15131717-15149833:- | 0.12 | 3.62 | 0.000322 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs7200543 | 1 | rs55727637 | chr16:15145252 | PDXDC1 | chr16:15068599-15233195:+ | 0.3 | 7.03 | 6.94E-12 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs867186 | 1 | rs55734215 | chr20:33585437 | PROCR | chr20:33758727-33765164:+ | -0.36 | -5.75 | 1.55E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs55734215 | chr20:33585437 | TRPC4AP | chr20:33590215-33680618:- | 0.32 | 3.88 | 0.000118 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs755109 | 1 | rs55737216 | chr9:100695901 | C9orf156 | chr9:100666772-100684852:- | -0.14 | -3.82 | 0.000153 | Quantitative traits |
| THCA | cis | rs3925075 | 1 | rs55742763 | chr16:31340368 | HSD3B7 | chr16:30996519-31000473:+ | -0.16 | -4.06 | 5.8E-5 | IgA nephropathy |
| THCA | cis | rs3925075 | 1 | rs55742763 | chr16:31340368 | ZNF843 | chr16:31446885-31454348:- | -0.16 | -3.35 | 0.000883 | IgA nephropathy |
| THCA | cis | rs6574644 | 1 | rs55744181 | chr14:81777794 | STON2 | chr14:81727000-81893748:- | 0.21 | 4.2 | 3.16E-5 | Obesity-related traits |